Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese.

Abstract

BACKGROUND:

Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population.

METHODS:

Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2+/-11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort.

RESULTS:

The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (beta=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (beta=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels.

CONCLUSIONS:

ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study.

• Authors: Bernard M Y Cheung, Kwok Leung Ong, Roberta V Cheung, Louisa Y F Wong, Nelson M S Wat, Sidney Tam, Gabriel M Leung, Chun Ho Cheng, Jean Woo, Edward D Janus, Chu Pak Lau, Tai Hing Lam, Karen S L Lam
• Journal: Clinical chemistry and laboratory medicine (Clin Chem Lab Med) Vol. 46 Issue 4 Pg. 523-7 ( 2008) ISSN: 1434-6621 [Print] Germany
• PMID: 18605934 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• C-Reactive Protein
• Alkaline Phosphatase

Topics

• Aged
• Alkaline Phosphatase (blood)
• C-Reactive Protein (biosynthesis)
• Cardiovascular Diseases (blood, diagnosis, ethnology)
• Female
• Hong Kong
• Humans
• Inflammation
• Liver (pathology)
• Male
• Middle Aged
• Multivariate Analysis
• Reference Values
• Risk Factors
• Sex Factors