Abstract | BACKGROUND: METHODS: RESULTS:
Losartan attenuated glomerular ROS production in DM. Accelerated ROS production and diminished bioavailable NO caused by NOS uncoupling were noted in DM glomeruli. Losartan reversed the decreased GTPCH1 and decreased dimeric form of eNOS and glomerular NO production by increased BH4 bioavailability. CONCLUSIONS:
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Authors | Minoru Satoh, Sohachi Fujimoto, Sayaka Arakawa, Toyotaka Yada, Tamehachi Namikoshi, Yoshisuke Haruna, Hideyuki Horike, Tamaki Sasaki, Naoki Kashihara |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 23
Issue 12
Pg. 3806-13
(Dec 2008)
ISSN: 1460-2385 [Electronic] England |
PMID | 18596126
(Publication Type: Journal Article)
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Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- DNA Primers
- RNA, Messenger
- Reactive Oxygen Species
- Biopterins
- Nitric Oxide
- Nitric Oxide Synthase Type III
- Nos3 protein, rat
- GTP Cyclohydrolase
- sapropterin
- Losartan
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Topics |
- Angiotensin II Type 1 Receptor Blockers
(pharmacology)
- Animals
- Base Sequence
- Biopterins
(analogs & derivatives, blood)
- DNA Primers
(genetics)
- Diabetes Mellitus, Experimental
(complications, drug therapy, enzymology)
- Diabetic Nephropathies
(drug therapy, enzymology, physiopathology)
- GTP Cyclohydrolase
(genetics, metabolism)
- Kidney Glomerulus
(metabolism)
- Losartan
(pharmacology)
- Male
- Nitric Oxide
(metabolism)
- Nitric Oxide Synthase Type III
(metabolism)
- Polymerase Chain Reaction
- RNA, Messenger
(genetics, metabolism)
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species
(metabolism)
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