Survivin and cyclin D1 are jointly expressed in thyroid papillary carcinoma and microcarcinoma.

Abstract

In order to define more effective predictive markers for clinical management and prognosis, we evaluated the expression of cyclin D1 and survivin in large papillary thyroid carcinoma (LPTC) and microcarcinoma (PTM). Sixty-seven patients operated for papillary carcinoma (36 of which with PTM) were considered. Immunochemistry for cyclin D1 and survivin was performed in samples from tumor mass and nodal metastases. There were not significant differences between LPTC and PTM as to patients personal data, TNM or MACIS staging, nodal invasion and multifocality, while capsular invasion was significantly more frequent in LPTC. Cyclin D1 and survivin were expressed at a very high rate and almost to the same extent in LPTC and PTM, both in tumoral mass and in nodal metastases. Survivin showed only cytoplasmic expression. Cyclin D1 and survivin over-expression are probably early events in tumorigenesis of thyroid papillary carcinoma but their full role in the process of tumor progression and their clinical value are still to be investigated.

• Authors: Alfredo Antonaci, Fabrizio Consorti, Stefania Mardente, Stefania Natalizi, Gloria Giovannone, Carlo Della Rocca
• Journal: Oncology reports (Oncol Rep) Vol. 20 Issue 1 Pg. 63-7 (Jul 2008) ISSN: 1021-335X [Print] Greece
• PMID: 18575719 (Publication Type: Journal Article)

Chemical References

• BIRC5 protein, human
• Inhibitor of Apoptosis Proteins
• Microtubule-Associated Proteins
• Neoplasm Proteins
• Survivin
• Cyclin D1

Topics

• Adolescent
• Adult
• Aged
• Carcinoma, Papillary (chemistry, pathology)
• Child
• Child, Preschool
• Cyclin D1 (analysis)
• Female
• Humans
• Immunohistochemistry
• Inhibitor of Apoptosis Proteins
• Lymphatic Metastasis
• Male
• Microtubule-Associated Proteins (analysis)
• Middle Aged
• Neoplasm Proteins (analysis)
• Survivin
• Thyroid Neoplasms (chemistry, pathology)