Abstract | AIM: Patients' outcomes after prolonged cardiac arrest are often grim. The aim of this study was to find the longest period of normovolemic, normothermic, cardiac arrest no-flow after which good neurologic outcome can be achieved with conventional therapies. METHODS: RESULTS: In the 13-min group, restoration of spontaneous circulation (ROSC) was achieved in five of six swine, four of which survived to day 9, and all had favorable neurologic outcomes [one swine OPC 1, three swine OPC 2, NDS 15% (IQR 6-21)]. In the 15- and 17-min groups, ROSC was achieved in three of six and two of six swine, respectively, one survived to day 9 with OPC 3 in each group, and NDS values were 45 and 58%, respectively (Kruskal-Wallis test for OPC, p=0.048). CONCLUSIONS: In our model, the limit of normovolemic, normothermic, cardiac arrest no-flow time, followed by ACLS, CPB, and prolonged mild hypothermia, seems to be 13 min.
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Authors | Andreas Janata, Keywan Bayegan, Fritz Sterz, Wolfgang Weihs, Michael Holzer, Wolfgang Sipos, Gregor Springler, Wilhelm Behringer |
Journal | Resuscitation
(Resuscitation)
Vol. 79
Issue 1
Pg. 133-8
(Oct 2008)
ISSN: 0300-9572 [Print] Ireland |
PMID | 18562071
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Analysis of Variance
- Animals
- Cardiopulmonary Resuscitation
(methods)
- Electric Countershock
- Epinephrine
(administration & dosage)
- Heart Arrest
(therapy)
- Heart Massage
(methods)
- Hypothermia, Induced
(methods)
- Random Allocation
- Swine
- Vasopressins
(administration & dosage)
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