Abstract | BACKGROUND: METHODS: We genotyped 96 individuals who had reached plasma TG concentrations of more than 10 mmol/L and 225 ischemic patients without severe HTG. RESULTS: Minor allele carriers were significantly more frequent in HTG group for all three polymorphisms (APOA5, APOE2 and APOE4). Adjusted individual risks for severe HTG were: APOA5 -1131C, OR=4.1 (95%CI:2.02-8.24); APOE2, OR=1.6 (95%CI:0.73-3.58); APOE4, OR=3.0 (95%CI:1.68-5.86). Adjusted risks for APOA5-APOE combinations were: APOA5 -1131C/ APOE2, OR=45.2 (95%CI:4.92-415.5); APOA5 -1131C/ APOE4, OR=6.4 (95%CI:2.28-18.01). CONCLUSIONS: These data provide evidence that APOA5 -1131T>C polymorphism is associated with risk for severe HTG. Furthermore, this effect is strongly increased when -1131C variant is combined with APOE variants.
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Authors | Marinez Oliveira Sousa, Pedro Alía, Xavier Pintó, Emili Corbella, Miguel-Angel Navarro |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 395
Issue 1-2
Pg. 68-71
(Sep 2008)
ISSN: 0009-8981 [Print] Netherlands |
PMID | 18549811
(Publication Type: Journal Article)
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Chemical References |
- APOA2 protein, human
- APOA5 protein, human
- Apolipoprotein A-II
- Apolipoprotein A-V
- Apolipoprotein E4
- Apolipoproteins A
- Apolipoproteins E
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Topics |
- Adult
- Aged
- Alleles
- Apolipoprotein A-II
(genetics, metabolism)
- Apolipoprotein A-V
- Apolipoprotein E4
(genetics, metabolism)
- Apolipoproteins A
(genetics, metabolism)
- Apolipoproteins E
(genetics, metabolism)
- Female
- Genotype
- Humans
- Hypertriglyceridemia
(blood, genetics, metabolism)
- Male
- Middle Aged
- Odds Ratio
- Point Mutation
- Polymorphism, Genetic
- Risk Factors
- Severity of Illness Index
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