The antiproliferative effect of bovine lactoferrin on canine mammary gland tumor cells.

Abstract

Lactoferrin has several biological activities, including antitumor activities in some human and animal tumor cells. Clinical trials have been carried out in human medicine based on these effects. However, the antitumor effects of lactoferrin in veterinary medicine remain unknown. In this in vitro study, we demonstrated that co-incubation of canine mammary gland tumor cells (CIPp and CHMp) and bovine lactoferrin induced growth arrest of tumor cells. This growth arrest was associated with induction of G1 arrest. Furthermore, this effect was stronger in tumor cells than in normal cells. These findings demonstrate that bovine lactoferrin has anti-tumor activity in canine mammary tumors and has the potential for use in tumor-bearing dogs.

• Authors: Yuichi Yamada, Reeko Sato, Saori Kobayashi, Careen Hankanga, Osamu Inanami, Mikinori Kuwabara, Yutaka Momota, Nobuyuki Tomizawa, Jun Yasuda
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 70 Issue 5 Pg. 443-8 (May 2008) ISSN: 0916-7250 [Print] Japan
• PMID: 18525164 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Lactoferrin

Topics

• Adenocarcinoma (drug therapy, veterinary)
• Animals
• Antineoplastic Agents (pharmacology)
• Cattle
• Cell Line, Tumor
• Dogs
• Dose-Response Relationship, Drug
• Lactoferrin (pharmacology)
• Mammary Neoplasms, Animal (drug therapy)
• Time Factors