The ApoC-I content of VLDL particles is associated with plaque size in persons with carotid atherosclerosis.

Abstract

Previous studies have shown that postprandial triglyceride-rich lipoproteins (TRLs) are enriched with apolipoprotein-C-I (apoC-I) in healthy individuals with increased intima-media thickness and in patients with coronary artery disease. The purpose of the present study was to determine apoC-I in TRL in persons with carotid atherosclerosis and its relation to plaque area. A population-based case (n = 42)-control (n = 39) study was conducted in persons with carotid atherosclerosis, assessed by B-mode ultrasound, and healthy controls. VLDL (Sf 20-400) was isolated in the fasting state and 4 h after ingestion of a standard fat meal. In the fasting state, persons with carotid atherosclerosis had increased number of apoC-I per VLDL-particle compared to persons without carotid atherosclerosis (8.6 +/- 5.4 vs. 6.3 +/- 4.2, P = 0.018). Total plaque area increased linearly (P = 0.017) across tertiles of apoC-I per VLDL-particle. In the postprandial state, a similar increase in the number of apoC-I per VLDL-particle occurred in both cases and controls (P < 0.001), but no significant difference was observed between groups. The number of apoC-I per VLDL-particle in the fasting state was accompanied by delayed clearance of TRL in the postprandial state, and associated with cholesterol enrichment of the VLDL-particles. Our findings support the concept that the number of apoC-I per VLDL-particle may be of importance for initiation and progression of atherosclerosis.

• Authors: Ann-Trude With Notø, Ellisiv Bøgeberg Mathiesen, Jan Brox, Johan Björkegren, John-Bjarne Hansen
• Journal: Lipids (Lipids) Vol. 43 Issue 7 Pg. 673-9 (Jul 2008) ISSN: 0024-4201 [Print] United States
• PMID: 18509687 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• APOC1 protein, human
• Apolipoprotein C-I
• Biomarkers
• Lipoproteins, VLDL

Topics

• Aged
• Apolipoprotein C-I (analysis)
• Biomarkers (analysis)
• Carotid Artery Diseases (blood, diagnostic imaging)
• Fasting
• Female
• Humans
• Lipoproteins, VLDL (blood, chemistry)
• Male
• Middle Aged
• Particle Size
• Predictive Value of Tests
• Reference Standards
• Ultrasonography