Oritavancin: a potential weapon in the battle against serious Gram-positive pathogens.

Abstract

Oritavancin is a lipoglycopeptide antibiotic with activity against aerobic and anaerobic Gram-positive bacteria. Oritavancin separates itself from other glycopeptides through its potent in vitro activity against resistant isolates of Staphylococcus aureus, Enterococcus spp. and Streptococcus spp. Oritavancin possesses a long half-life that should allow, at maximum, once-daily dosing. Currently, oritavancin has completed two Phase III trials and one Phase II trial for the treatment of complicated skin and skin structure infections, and two Phase II trials for the treatment of Gram-positive bacteremia. In all instances, oritavancin displayed favorable outcomes and was noninferior to comparator agents (vancomycin followed by oral cephalexin) when a comparison was made. Further studies are necessary to fully characterize dose and clinical role.

• Authors: Jared Crandon, David P Nicolau
• Journal: Future microbiology (Future Microbiol) Vol. 3 Issue 3 Pg. 251-63 (Jun 2008) ISSN: 1746-0921 [Electronic] England
• PMID: 18505390 (Publication Type: Comparative Study, Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Glycopeptides
• Lipoglycopeptides
• oritavancin

Topics

• Anti-Bacterial Agents (pharmacokinetics, pharmacology, therapeutic use)
• Bacteremia (drug therapy)
• Glycopeptides (pharmacokinetics, pharmacology, therapeutic use)
• Gram-Positive Bacteria (drug effects)
• Gram-Positive Bacterial Infections (drug therapy)
• Half-Life
• Humans
• Lipoglycopeptides
• Soft Tissue Infections (drug therapy)
• Treatment Outcome