Abstract | AIM: METHODS: RESULTS: The results showed that the genotype frequencies of CC, CT, and TT at 801C>T locus were significantly different among the patients of the 4 groups who were classified by quartile values of GS (P=0.033). However, the frequency of the 847T allele was 0 for all the patients. The ordinal logistic regression analysis revealed that the increased risk of angiographical characteristics of coronary atherosclerosis were associated with CPE 801CT/TT variant genotypes [adjusted odds ratio (OR)=1.23, 95% confidence interval (CI) =0.93-1.63 for 801CT and adjusted OR=3.13, 95% CI=1.18-8.28 for 801TT] compared with the 801CC wild-type homozygotes. A stratification analysis showed that the effects of the CPE 801TT genotype were more evident among subgroups with relatively older (> or = 60 years) patients, males, and smokers. Furthermore, an analysis of covariance controlling age, sex, and body mass index indicated that differences of blood glucose, insulin, insulin resistance, and the proinsulin level between 801C>T genotype groups were not statistically significant. CONCLUSION: These findings indicate that the 801C>T polymorphism in the CPE exon5 gene may contribute to the angiographical characteristics of coronary atherosclerosis in the Chinese population.
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Authors | Jie Wang, Yun Zhang, Zhi-jian Yang, Tie-bing Zhu, Lian-sheng Wang, Bo Chen, Ke-jiang Cao, Jun Huang, Wen-zhu Ma, En-zhi Jia |
Journal | Acta pharmacologica Sinica
(Acta Pharmacol Sin)
Vol. 29
Issue 6
Pg. 736-44
(Jun 2008)
ISSN: 1745-7254 [Electronic] United States |
PMID | 18501121
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Anthropometry
- Atherosclerosis
(epidemiology, genetics, pathology)
- Carboxypeptidase H
(genetics)
- China
(epidemiology)
- Coronary Angiography
- DNA
(genetics, isolation & purification)
- Exons
(genetics)
- Female
- Gene Frequency
- Humans
- Male
- Middle Aged
- Odds Ratio
- Polymorphism, Genetic
(genetics)
- Polymorphism, Single Nucleotide
- Reverse Transcriptase Polymerase Chain Reaction
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