[Effects of vasotocin analogs on excretion of Na+, K+, and Mg2+ ions via rat kidney].

Abstract

Experiments on rats showed that the intramuscular injections of arginine-vasotocin (AVT), 1-deamino-arginine-vasotocin (1dAVT) or 1-deamino-1-monocarba-arginine-vasotocin (1dlmcAVT) at a dose of 5 x 10(-11) mole per 100 g body weight increase renal excretion of Na+, K+, and Mg2+. Antagonist of V1 receptors (OPC-21268) decreases the effect of 1dAVT nonapeptides on renal excretion of the studied ions. A model of VIb-receptor is constructed and a correlation is shown between the energy of interaction of the V1b-receptor and the natriuretic effect of the studied vasotocin analogs.

• Authors: Iu V Natochin, T A Kanashkina, E I Shakhmatova, Zh D Bespalova, D Iu Mordvintsev, Ia L Poliak
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2008 Mar-Apr Vol. 71 Issue 2 Pg. 32-5 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 18488904 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antidiuretic Hormone Receptor Antagonists
• Cations
• Receptors, Vasopressin
• Sodium
• Magnesium
• Potassium
• Vasotocin

Topics

• Animals
• Antidiuretic Hormone Receptor Antagonists
• Cations (metabolism)
• Diuresis (drug effects, physiology)
• Female
• Ion Transport
• Kidney (drug effects, physiology)
• Magnesium (metabolism)
• Models, Molecular
• Potassium (metabolism)
• Rats
• Receptors, Vasopressin (physiology)
• Sodium (metabolism)
• Vasotocin (analogs & derivatives, pharmacology)