[Reduction of oxaliplatin-related neurotoxicity by Gosha-jinki-gan].

Abstract

PURPOSE:

Oxaliplatin in combination with infusional 5-fluorouracil/Leucovorin (FOLFOX) has emerged as the treatment of choice for advanced-stage colorectal cancer. Sensory neurotoxicity is its dose-limiting toxicity. We decided to use Gosha-jinki-gan for prevention of oxaliplatin-related neurotoxicity following the report of Fushiki et al.

METHODS:

The subjects were 14 patients with metastatic colorectal cancer. Oxaliplatin (85 mg/m(2)) was given intravenously as a FOLFOX4 regimen. All 14 patients received Gosha-jinki-gan every day after first oxaliplatin infusion.

RESULT:

7 patients had grade 3 toxicity(neutropenia 6, thrombocytopenia 1). Sensory neuropathy occurred in 10 patients (71.4%). There was no neurotoxicity with functional impairment in this study.

CONCLUSIONS:

Gosha-jinki-gan seems to prevent acute oxaliplatin-induced neurotoxicity.

• Authors: Yoshiaki Shindo, Kazuo Tenma, Hiroshi Imano, Masanori Hibino, Kei Yoshino, Masaaki Nakamura
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 35 Issue 5 Pg. 863-5 (May 2008) ISSN: 0385-0684 [Print] Japan
• PMID: 18487931 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Drugs, Chinese Herbal
• Organoplatinum Compounds
• gosha-jinki-gan
• Oxaliplatin
• Leucovorin
• Fluorouracil

Topics

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Agents (toxicity)
• Antineoplastic Combined Chemotherapy Protocols (toxicity)
• Colorectal Neoplasms (drug therapy)
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Fluorouracil (toxicity)
• Humans
• Leucovorin (toxicity)
• Male
• Middle Aged
• Organoplatinum Compounds (toxicity)
• Oxaliplatin
• Peripheral Nerves (drug effects)
• Peripheral Nervous System Diseases (prevention & control)