Postprandial triglyceride metabolism in elderly men with subnormal testosterone levels.

Abstract

AIM:

To investigate the level of postprandial triglycerides (TG)s in elderly men with subnormal testosterone level (< or = 11.0 nmol/L) compared to men with normal testosterone level (> 11.0 nmol/L).

METHODS:

Thirty-seven men with subnormal and 41 men with normal testosterone aged 60-80 years underwent an oral fat load and TG levels were measured fasting and 2, 4, 6 and 8 h afterwards.

RESULTS:

Men with subnormal testosterone had significantly higher body mass index (BMI) and waist circumference (P < 0.001) than men with normal testosterone. They had significantly higher area under curve (AUC, P = 0.037), incremental area under curve (AUCi, P = 0.035) and TG response (TGR, P = 0.014) for serum-TG and significantly higher AUC (P = 0.023), AUCi (P = 0.023) and TGR (P = 0.014) for chylomicron-TG compared to men with normal testosterone level. Adjusting for waist circumference erased the significant differences between the groups in postprandial triglyceridemia.

CONCLUSION:

Men with subnormal testosterone have increased postprandial TG levels indicating an impaired metabolism of postprandial TG-rich lipoproteins (TRL), which may add to an unfavourable lipid profile and promote development of atherosclerosis.

• Authors: Ingvild Agledahl, John-Bjarne Hansen, Johan Svartberg
• Journal: Asian journal of andrology (Asian J Androl) Vol. 10 Issue 4 Pg. 542-9 (Jul 2008) ISSN: 1008-682X [Print] China
• PMID: 18478157 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Triglycerides
• Testosterone

Topics

• Aged
• Aged, 80 and over
• Body Mass Index
• Case-Control Studies
• Humans
• Lipid Metabolism (physiology)
• Male
• Middle Aged
• Postprandial Period (physiology)
• Testosterone (deficiency)
• Time Factors
• Triglycerides (metabolism)