Distinct evolution of calcium channel antibody types in Lambert-Eaton myasthenic syndrome.

Abstract

To determine whether titers of anti-P/Q type and anti-N type calcium channel antibodies provide distinct information, both types of assay were performed during follow-up of 7 patients with Lambert-Eaton myasthenic syndrome (LEMS). In 4 patients with both antibody responses, titers evolved independently and often in an inverse relationship. Two patients with squamous cell lung carcinoma (SqCLC) produced anti-N type channel antibodies, but no detectable anti-P/Q channel responses. These results suggest that anti-N channel autoantibodies constitute an immune response distinct from the anti-P/Q type channel specificity and can also correlate with clinical evolution. Consequently combined assays may provide more comprehensive information during follow-up of LEMS.

• Authors: Nicole Martin-Moutot, Luc De Haro, Michael Seagar
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 197 Issue 1 Pg. 47-53 (Jun 15 2008) ISSN: 0165-5728 [Print] Netherlands
• PMID: 18474401 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Calcium Channels, N-Type
• Calcium Channels, P-Type
• Calcium Channels, Q-Type

Topics

• Aged
• Autoantibodies (biosynthesis, blood, classification)
• Calcium Channels, N-Type (immunology)
• Calcium Channels, P-Type (immunology)
• Calcium Channels, Q-Type (immunology)
• Carcinoma, Small Cell (diagnosis, immunology, therapy)
• Carcinoma, Squamous Cell (diagnosis, immunology, therapy)
• Evolution, Molecular
• Female
• Humans
• Lambert-Eaton Myasthenic Syndrome (diagnosis, immunology, therapy)
• Lung Neoplasms (diagnosis, immunology, therapy)
• Male
• Middle Aged