The synergistic effect of 1-hydroxyanthraquinone on methylazoxymethanol acetate-induced carcinogenesis in rats.

Abstract

The synergistic potential of 1-hydroxyanthraquinone (1-HA) on methylazoxymethanol (MAM) acetate-induced carcinogenesis was investigated in rats. A total of 154 inbred ACI/N rats (73 males and 81 females), six weeks old at the start of the experiment, were divided into four groups: group 1 was given i.p. injections of MAM acetate (25 mg/kg body wt), once per week for 2 weeks and then fed the diet containing 1% 1-HA for 42 weeks; group 2 received MAM acetate and was kept on the basal diet alone; group 3 was given 1-HA containing diet alone as for group 1; group 4 was treated as a control. At the termination of the experiment, the carcinogenic effect of MAM acetate and 1-HA in the large bowel or liver exceeded the sum of effects when given alone, indicating that the two chemicals act synergistically in the carcinogenesis of these organs.

• Authors: Y Mori, N Yoshimi, H Iwata, T Tanaka, H Mori
• Journal: Carcinogenesis (Carcinogenesis) Vol. 12 Issue 2 Pg. 335-8 (Feb 1991) ISSN: 0143-3334 [Print] England
• PMID: 1847322 (Publication Type: Journal Article)

Chemical References

• Anthraquinones
• Methylazoxymethanol Acetate
• 1-hydroxyanthraquinone

Topics

• Administration, Oral
• Animals
• Anthraquinones (administration & dosage, toxicity)
• Carcinoma, Hepatocellular (chemically induced)
• Drug Synergism
• Female
• Injections, Intraperitoneal
• Intestinal Neoplasms (chemically induced)
• Liver (cytology, drug effects)
• Male
• Methylazoxymethanol Acetate (administration & dosage, toxicity)
• Neoplasms, Experimental (chemically induced)
• Rats
• Rats, Inbred Strains