Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia.

Abstract

Catecholaminergic polymorphic ventricular tachycardia is a potentially lethal disease characterized by adrenergically mediated ventricular arrhythmias manifested especially in children and teenagers. Beta-blockers are the cornerstone of therapy, but some patients do not have a complete response to this therapy and receive an implantable cardioverter-defibrillator (ICD). Given the nature of catecholaminergic polymorphic ventricular tachycardia, ICD shocks may trigger new arrhythmias, leading to the administration of multiple shocks. We describe the long-term efficacy of surgical left cardiac sympathetic denervation in three young adults with catecholaminergic polymorphic ventricular tachycardia, all of whom had symptoms before the procedure and were symptom-free afterward.

• Authors: Arthur A M Wilde, Zahurul A Bhuiyan, Lia Crotti, Mario Facchini, Gaetano M De Ferrari, Thomas Paul, Chiara Ferrandi, Dave R Koolbergen, Attilio Odero, Peter J Schwartz
• Journal: The New England journal of medicine (N Engl J Med) Vol. 358 Issue 19 Pg. 2024-9 (May 08 2008) ISSN: 1533-4406 [Electronic] United States
• PMID: 18463378 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2008 Massachusetts Medical Society.

Chemical References

• Catecholamines

Topics

• Adolescent
• Catecholamines
• Defibrillators, Implantable
• Electrocardiography
• Female
• Follow-Up Studies
• Heart (innervation)
• Humans
• Male
• Sympathectomy
• Tachycardia, Ventricular (physiopathology, surgery, therapy)