Nonalcoholic fatty liver in patients with Laron syndrome and GH gene deletion - preliminary report.

Abstract

BACKGROUND:

There is little information on the relationship between growth hormone/insulin-like growth factor-I (GH/IGF-I) deficiency or IGF-I treatment on nonalcoholic fatty liver disease (NAFLD) a disorder linked to obesity and insulin resistance.

OBJECTIVE:

To find out whether the markedly obese patients with Laron syndrome (LS) and GH gene deletion have fatty livers.

SUBJECTS:

We studied 11 untreated adult patients with LS (5M, 6F), five girls with LS treated by IGF-I and five adult patients with GH gene deletion (3M, 3F), four previously treated by hGH in childhood.

METHODS:

Fatty liver was quantitatively evaluated by ultrasonography using a phase array US system (HITACHI 6500, Japan). Body adiposity was determined by DEXA, and insulin resistance was estimated by HOMA-IR using the fasting serum glucose and insulin values.

RESULTS:

Six out of 11 adult patients with LS, two out of the five IGF-I treated girls with LS and three out of five adult hGH gene deletion patients were found to have NAFLD (nonalcoholic fatty liver disease).

CONCLUSION:

NAFLD is a frequent complication in untreated and treated congenital IGF-I deficiency. No correlation between NAFLD and age, sex, degree of obesity, blood lipids, or degree of insulin resistance was observed.

• Authors: Zvi Laron, Shira Ginsberg, Muriel Webb
• Journal: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society (Growth Horm IGF Res) Vol. 18 Issue 5 Pg. 434-438 (Oct 2008) ISSN: 1096-6374 [Print] Scotland
• PMID: 18462969 (Publication Type: Journal Article)

Chemical References

• Human Growth Hormone
• Insulin-Like Growth Factor I

Topics

• Adult
• Fatty Liver (diagnostic imaging, etiology, metabolism)
• Female
• Gene Deletion
• Human Growth Hormone (genetics, metabolism)
• Humans
• Insulin Resistance
• Insulin-Like Growth Factor I (deficiency)
• Laron Syndrome (complications, metabolism)
• Male
• Middle Aged
• Ultrasonography