Abstract | OBJECTIVE: METHODS: Studies were prospective, comparative, multicentre and randomised. Comparators were penicillin V ( pharyngitis) and cefuroxime or amoxicillin/ clavulanate ( sinusitis). A total of 1,322 patients were randomized, 1,241 included in intention-to-treat (ITT) and 1,010 in per-protocol populations (PP) in pharyngotonsillitis studies, and 1,819 randomized, 1,726 included in ITT and 1,589 in PP in acute sinusitis studies. RESULTS: No significant differences in pharyngitis clinical response were found (success rates: 89.4 % to 95.3 %). S. pyogenes eradication was higher with cefditoren at end of therapy (EOT) (90.4% vs. 82.7%; p=0.002) and follow-up (84.7% vs. 76.7%; p=0.008), although no statistically significant (p<0.001). In both groups, clinical failures were significantly higher (p<0.001) in patients showing S. pyogenes persistence than in those showing eradication (> or =98.5% vs. 51.4 %). No differences in sinusitis clinical response were found between CDN and comparators both at EOT (80.2% vs. 84.8%) and at end of follow-up (71.2% vs. 77.4%). CONCLUSION:
Cefditoren had similar point estimates of clinical efficacy to comparators in pharyngotonsillitis and sinusitis, and a tendency to higher S. pyogenes eradication in pharyngotonsillitis.
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Authors | J J Granizo, M J Giménez, J Barberán, P Coronel, M Gimeno, L Aguilar |
Journal | Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia
(Rev Esp Quimioter)
Vol. 21
Issue 1
Pg. 14-21
(Mar 2008)
ISSN: 0214-3429 [Print] Spain |
PMID | 18443928
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Cephalosporins
- cefditoren
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Topics |
- Anti-Bacterial Agents
(therapeutic use)
- Cephalosporins
(therapeutic use)
- Humans
- Randomized Controlled Trials as Topic
- Respiratory Tract Infections
(drug therapy)
- Treatment Outcome
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