[The effect of tienamycin on selected cellular immunologic parameters in mice during the course of viral-bacterial infections of the respiratory system].

Abstract

The effect of tienamycin on selected parameters of the immunological system in mice infected with the influenza virus and Staphylococcus aureus was studied. Tienamycin was administered 24 hours, 2 hours prior the infection and 2 hours after the infection (model I), 24 hours and 48 hours after infecting the mice (model II). The authors analysed phagocytosis, bactericidal activity of peritoneal exudate cells and the LIF release induced by the staphylococcus antigen and the viral antigen by the spleen mice leukocytes. The authors found that the antibiotic given to non-infected mice inhibited phagocytosis of staphylococci by the peritoneal exudate cells. In mice that were infected a positive effect of the antibiotic on all studied parameters. Administering the antibiotic before infecting the mice produced an even better effect.

• Authors: I Ciebiada, E Korczak, T Ferszt, A Denys, M Kowalska
• Journal: Pneumonologia i alergologia polska (Pneumonol Alergol Pol) Vol. 59 Issue 9-10 Pg. 5-10 ( 1991) ISSN: 0867-7077 [Print] Poland
• Vernacular Title: Wpływ tienamycyny na wybrane parametry odpowiedzi komórkowej u myszy w przebiegu zakazeń wirusowo-bakteryjnych układu oddechowego.
• PMID: 1843648 (Publication Type: Journal Article)

Chemical References

• Thienamycins
• thienamycin

Topics

• Animals
• Bacterial Infections (drug therapy, immunology)
• Haemophilus Infections (drug therapy, immunology)
• Haemophilus influenzae
• Immunity, Cellular (drug effects)
• Mice
• Mice, Inbred BALB C
• Respiratory Tract Infections (drug therapy, immunology)
• Staphylococcus (drug effects)
• Thienamycins (pharmacology)