Abstract |
Breast cancer can be classified into several subtypes based on gene expression profiling. Basal-like breast carcinoma (BLC) has a triple negative phenotype, that is, the subtype lacks the estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor 2 (HER2). It has been recently reported that CD109, a glycosylphosphatidylinositol (GPI)-anchored cell surface protein, is a new breast myoepithelial marker. In the present study CD109 expression was investigated in invasive ductal carcinomas (IDC) of the breast on immunohistochemistry. Eighty-eight formalin-fixed, paraffin-embedded breast carcinoma sections were immunostained with anti-CD109, anti- cytokeratin 5/6 (CK5/6), anti- calponin, anti- vimentin and anti-p63 antibodies. CD109 expression was detected in 18 of 30 basal-like breast carcinomas (BLC) but not in other types of 53 IDC (non-BLC) that were positive for ER, PgR and/or HER2. The percentage of CD109-positive tissues (60%) in BLC was similar to that of CK5/6 (63%) and higher than that of other myoepithelial markers including p63 (23%), calponin (33%) and vimentin (33%). Statistical analysis indicated that the CD109-positive group in BLC, but not the CK5/6-positive group in BLC, was associated with reduced fat invasion (P < 0.05). These findings indicate that CD109 is a useful diagnostic marker for BLC and that CD109 expression may affect biological properties of cancer cells.
|
Authors | Masaki Hasegawa, Suzuko Moritani, Yoshiki Murakumo, Tomoko Sato, Sumitaka Hagiwara, Chikage Suzuki, Shinji Mii, Mayumi Jijiwa, Atsushi Enomoto, Naoya Asai, Shu Ichihara, Masahide Takahashi |
Journal | Pathology international
(Pathol Int)
Vol. 58
Issue 5
Pg. 288-94
(May 2008)
ISSN: 1440-1827 [Electronic] Australia |
PMID | 18429827
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antigens, CD
- Antigens, Neoplasm
- Biomarkers, Tumor
- CD109 protein, human
- GPI-Linked Proteins
- Neoplasm Proteins
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD
(metabolism)
- Antigens, Neoplasm
(metabolism)
- Biomarkers, Tumor
(metabolism)
- Breast
(metabolism, pathology)
- Breast Neoplasms
(metabolism, pathology)
- Carcinoma, Ductal, Breast
(metabolism, pathology)
- Female
- Fluorescent Antibody Technique, Indirect
- GPI-Linked Proteins
- Humans
- Immunoenzyme Techniques
- Middle Aged
- Neoplasm Proteins
(metabolism)
|