Cytotoxic triterpenoids from the root bark of Helicteres angustifolia.

Abstract

Three new triterpenoids, 3beta-acetoxy-27-[(E)-cinnamoyloxy]lup-20(29)-en-28-oic acid methyl ester (1), 3beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]lup-20(29)-en-28-oic acid (2), and 3beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]olean-12-en-28-oic acid methyl ester (3), together with nine known triterpenoids, 4-12, were isolated from the root bark of Helicteres angustifolia. The structures of these compounds were established on the basis of spectroscopic methods including 2D-NMR experiments. All twelve compounds were tested for their cytotoxic activities against human colorectal cancer (COLO 205), human hepatoma (Hep G2), and human gastric cancer (AGS) cell lines in vitro. Among them, compounds 2, 3, 3beta-O-[(E)-coumaroyl]betulinic acid (6), and pyracrenic acid (7) showed significant cytotoxic activities against human cancer cells COLO 205 and AGS.

• Authors: Min-Hsiung Pan, Chiu-Ming Chen, Shwu-Woan Lee, Zong-Tsi Chen
• Journal: Chemistry & biodiversity (Chem Biodivers) Vol. 5 Issue 4 Pg. 565-74 (Apr 2008) ISSN: 1612-1880 [Electronic] Switzerland
• PMID: 18421748 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Triterpenes

Topics

• Carcinoma, Hepatocellular (drug therapy)
• Colorectal Neoplasms (drug therapy)
• Humans
• Malvaceae (chemistry)
• Plant Bark (chemistry)
• Plant Roots (chemistry)
• Stomach Neoplasms (drug therapy)
• Structure-Activity Relationship
• Triterpenes (chemistry, pharmacology, therapeutic use)
• Tumor Cells, Cultured (drug effects)