Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course.

Abstract

Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4+ T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably.

• Authors: Giulia Freer, Donatella Matteucci, Paola Mazzetti, Francesca Tarabella, Enrica Ricci, Leonia Bozzacco, Antonio Merico, Mauro Pistello, Luca Ceccherini-Nelli, Mauro Bendinelli
• Journal: Retrovirology (Retrovirology) Vol. 5 Pg. 33 (Apr 17 2008) ISSN: 1742-4690 [Electronic] England
• PMID: 18416857 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vaccines, Inactivated
• Viral Vaccines

Topics

• Animals
• CD4-Positive T-Lymphocytes (cytology)
• Cats
• Cell Proliferation
• Dendritic Cells (virology)
• Feline Acquired Immunodeficiency Syndrome (immunology, therapy, virology)
• Immunity, Cellular
• Immunodeficiency Virus, Feline (immunology, physiology)
• Immunotherapy (methods)
• Vaccines, Inactivated (administration & dosage, immunology)
• Viral Load
• Viral Vaccines (administration & dosage, immunology)