Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance.

Abstract

OBJECTIVES:

The aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance.

DESIGN AND METHODS:

We studied 112 patients with T2DM and 80 age- and gender-matched control subjects.

RESULTS:

Serum BDNF levels were significantly lower in patients with T2DM compared to control subjects (15.5+/-5.2 ng/mL vs. 20.0+/-7.3 ng/mL, P<0.01). In patients with T2DM, BDNF levels were significantly higher in females than in males (P<0.01). In the female patients, BDNF was positively related to immunoreactive insulin (IRI) (rho=0.458, P<0.05) and HOMA-R (rho=0.444, P<0.05). Stepwise multiple regression analysis showed a significant relationship between BDNF and IRI (F=5.294, P<0.05) in female patients with diabetes.

CONCLUSIONS:

These findings suggest that BDNF may contribute to glucose metabolism.

• Authors: Aya Fujinami, Kiyoe Ohta, Hiroshi Obayashi, Michiaki Fukui, Goji Hasegawa, Naoto Nakamura, Hana Kozai, Saeko Imai, Mitsuhiro Ohta
• Journal: Clinical biochemistry (Clin Biochem) Vol. 41 Issue 10-11 Pg. 812-7 (Jul 2008) ISSN: 1873-2933 [Electronic] United States
• PMID: 18402781 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adiponectin
• Blood Glucose
• Brain-Derived Neurotrophic Factor
• Insulin
• Leptin
• Creatinine

Topics

• Adiponectin (blood)
• Aged
• Albuminuria
• Blood Glucose (metabolism)
• Blood Pressure
• Brain-Derived Neurotrophic Factor (blood)
• Creatinine (urine)
• Diabetes Mellitus, Type 2 (blood)
• Female
• Humans
• Insulin (blood)
• Insulin Resistance (physiology)
• Leptin (blood)
• Male
• Middle Aged
• Patient Selection
• Reference Values