Hyperbaric oxygen treatment restores sudden hearing loss in a patient with Fabry disease.

Abstract	Fabry disease is an X-linked inherited disorder of glycosphingolipid metabolism due to the deficient activity of a lysosomal enzyme, alpha-galactosidase A. The resultant systemic accumulation of sphingolipids can lead to progressive and sudden hearing loss alongside renal, cardiac and cerebrovascular complications. Although replacement therapy seems to be beneficial for cochlear function, few data are available regarding treatment of sudden hearing loss. This case report describes the course of a unilateral sudden hearing loss in a young (15-year-old) male patient and its improvement following hyperbaric oxygen treatment.
Authors	Markus C Frantz, Bertram F Pontz, Wolfgang Arnold
Journal	ORL; journal for oto-rhino-laryngology and its related specialties (ORL J Otorhinolaryngol Relat Spec) Vol. 70 Issue 3 Pg. 210-3 ( 2008) ISSN: 1423-0275 [Electronic] Switzerland
PMID	18401198 (Publication Type: Case Reports, Journal Article)
Copyright	2008 S. Karger AG, Basel
Topics	Adolescent Audiometry Audiometry, Speech Fabry Disease (complications, physiopathology) Hearing Hearing Loss, Sudden (diagnosis, etiology, therapy) Hearing Loss, Unilateral (diagnosis, etiology, therapy) Humans Hyperbaric Oxygenation Male Recovery of Function Treatment Outcome

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