Abstract | UNLABELLED: AIM: STUDY DESIGN: Clinical and Experimental. METHODS: 25 guinea pigs were submitted to the application of a 100% propylene glycol solution in their bulla bilaterally and a solution of trans-retinoic acid was applied locally in the external right ear, while in the left ear saline solution was applied (control ear). The guinea pigs were slaughtered and their temporal bones were prepared for macroscopic and histological analysis. RESULTS: The macroscopic findings had evidenced the presence of cholesteatoma in 25% of the right ears and 85% of the left ears (P=0.0003 *). The histological study had evidenced the presence of cholesteatoma in 30% of right ears and 75% of the left ears (P=0.0104*). CONCLUSION:
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Authors | Marcos Luiz Antunes, Yotaka Fukuda, Norma de Oliveira Penido, Rimarcs Ferreira |
Journal | Brazilian journal of otorhinolaryngology
(Braz J Otorhinolaryngol)
2008 Jan-Feb
Vol. 74
Issue 1
Pg. 53-60
ISSN: 1808-8694 [Print] Brazil |
PMID | 18392502
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Tretinoin
- Propylene Glycol
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Topics |
- Administration, Cutaneous
- Animals
- Antineoplastic Agents
(therapeutic use)
- Cholesteatoma, Middle Ear
(chemically induced, pathology, prevention & control)
- Disease Models, Animal
- Female
- Guinea Pigs
- Male
- Propylene Glycol
- Prospective Studies
- Tretinoin
(therapeutic use)
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