Abstract | BACKGROUND: METHODS: Between June 1973 and December 2006, 2,142 patients underwent parathyroidectomy (PTx) for secondary HPT in our department. We encountered five (0.23%) patients with distant metastatic parathyroid tumors. We evaluated the immunohistochemistry for parafibromin in eight primary parathyroid glands removed from the neck at the initial operation and/or at reoperation and seven distant metastatic tumors resected at reoperation. RESULTS: In only one lung metastatic parathyroid tumor, negative staining for parafibromin was detected. In the other three lung, two regional node, and one chest wall metastatic parathyroid tumor, parafibromin was strongly stained in the nuclei of the parathyroid cells. Among eight primary glands, except for one with weakly positive staining, the expression of parafibromin was detected diffusely and strongly. CONCLUSION: We conclude that the inactivating mutations and/or allelic loss of the HRPT2 gene may not play a major role in parathyroid carcinogenesis in secondary HPT due to CKD, but in these cases cancer development may be associated with a heterogeneous genetic disorder.
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Authors | Yoshihiro Tominaga, Toyonori Tsuzuki, Susumu Matsuoka, Nobuaki Uno, Tetsuhiko Sato, Syuichi Shimabukuro, Norihiko Goto, Takaharu Nagasaka, Kazuharu Uchida |
Journal | World journal of surgery
(World J Surg)
Vol. 32
Issue 5
Pg. 815-21
(May 2008)
ISSN: 0364-2313 [Print] United States |
PMID | 18338208
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- CDC73 protein, human
- Tumor Suppressor Proteins
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Topics |
- Adult
- Cohort Studies
- Disease-Free Survival
- Female
- Humans
- Hyperparathyroidism, Secondary
(etiology, metabolism, surgery)
- Kidney Failure, Chronic
(etiology, metabolism, therapy)
- Male
- Middle Aged
- Parathyroid Neoplasms
(genetics, pathology, surgery)
- Parathyroidectomy
- Renal Dialysis
- Retrospective Studies
- Thoracic Neoplasms
(metabolism, secondary, surgery)
- Treatment Outcome
- Tumor Suppressor Proteins
(genetics, metabolism)
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