Abstract | OBJECTIVE: We evaluated the association of biomarkers of endothelial dysfunction and inflammation with all-cause mortality and cardiovascular mortality and morbidity and decline in glomerular filtration rate (GFR) in type 1 diabetic patients. RESEARCH DESIGN AND METHODS: We prospectively followed 199 type 1 diabetic patients with diabetic nephropathy and 192 patients with persistent normoalbuminuria. Biomarkers were measured at baseline. RESULTS: CONCLUSIONS: Mean Z scores of inflammatory biomarkers are significantly associated with all-cause mortality and cardiovascular morbidity and mortality in patients with nephropathy after multivariate adjustment. These data suggest that the high risk of cardiovascular disease in type 1 diabetes may be explained in part by inflammatory activity. Mean Z score of endothelial dysfunction correlated after multivariate adjustment with the rate of decline in GFR.
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Authors | Anne Sofie Astrup, Lise Tarnow, Lotte Pietraszek, Casper G Schalkwijk, Coen D A Stehouwer, Hans-Henrik Parving, Peter Rossing |
Journal | Diabetes care
(Diabetes Care)
Vol. 31
Issue 6
Pg. 1170-6
(Jun 2008)
ISSN: 1935-5548 [Electronic] United States |
PMID | 18332153
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Interleukin-6
- Intercellular Adhesion Molecule-1
- C-Reactive Protein
- Phospholipases A2
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Topics |
- Albuminuria
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- Diabetes Mellitus, Type 1
(complications, physiopathology)
- Diabetic Nephropathies
(mortality, physiopathology)
- Endothelium, Vascular
(physiopathology)
- Follow-Up Studies
- Glomerular Filtration Rate
- Humans
- Inflammation
(etiology, physiopathology)
- Intercellular Adhesion Molecule-1
(blood)
- Interleukin-6
(blood)
- Phospholipases A2
(blood)
- Time Factors
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