Abstract | PURPOSE: METHODS: In a retrospective case series, four patients with vascularly active FEVR, as demonstrated by increasing subretinal exudation despite photocoagulation, cryotherapy, and/or intravitreal steroid injection, received a single intravitreal injection of pegaptanib sodium. Preinjection and postinjection fundus photography, fluorescein angiography, and optical coherence tomography were performed to evaluate the changes in visual acuity, vascular activity, and amount of exudation. RESULTS: The mean follow-up period was 11.2 months (range, 8.1-15.5 months) after the first intravitreal injection. All four patients had a decrease in exudation after treatment with pegaptanib sodium documented by a decrease in subretinal exudate by fundus photography and decreased leakage by fluorescein angiography. After reduction of exudation, two patients required vitrectomy to relieve vitreoretinal traction. Visual acuity improved in two patients, stabilized in one patient, and worsened in one patient secondary to tractional retinal detachment. No injection-associated systemic or ocular complications were observed in any of the treated patients. CONCLUSIONS:
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Authors | Polly A Quiram, Kimberly A Drenser, Michael M Lai, Antonio Capone Jr, Michael T Trese |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 28
Issue 3 Suppl
Pg. S8-12
(Mar 2008)
ISSN: 0275-004X [Print] United States |
PMID | 18317351
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aptamers, Nucleotide
- pegaptanib
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Topics |
- Adolescent
- Aptamers, Nucleotide
(administration & dosage)
- Child, Preschool
- Female
- Humans
- Injections
- Male
- Retinal Diseases
(drug therapy, genetics)
- Retrospective Studies
- Treatment Outcome
- Visual Acuity
- Young Adult
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