A controlled comparative study of chlorprothixene vs. haloperidol in chronic schizophrenia.

Abstract

Neurochemical distinctions have been made between neuroleptic drugs that affect D-1 receptors as well as D-2 receptors, compared with those neuroleptic drugs that affect only D-2 receptors. However, a controlled double-blind study of haloperidol vs. chlorprothixene in schizophrenic patients found no significant differences.

• Authors: M Fux, R H Belmaker
• Journal: The Israel journal of psychiatry and related sciences (Isr J Psychiatry Relat Sci) Vol. 28 Issue 1 Pg. 37-40 ( 1991) ISSN: 0333-7308 [Print] Israel
• PMID: 1830565 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Receptors, Dopamine
• Receptors, Dopamine D1
• Receptors, Dopamine D2
• Chlorprothixene
• Haloperidol

Topics

• Adult
• Brain (drug effects)
• Chlorprothixene (adverse effects, therapeutic use)
• Chronic Disease
• Female
• Haloperidol (adverse effects, therapeutic use)
• Humans
• Male
• Middle Aged
• Receptors, Dopamine (drug effects)
• Receptors, Dopamine D1
• Receptors, Dopamine D2
• Schizophrenia (drug therapy)
• Schizophrenic Psychology