Recent advances in esophageal cancer gene therapy.

Abstract

In recent years, the development of gene therapy systems as new treatment or prevention strategies for various malignant diseases has been explored. Based on the genetic background of esophageal cancer, several molecular therapies have been developed. In this article, we review p53 genetic alterations and angiogenesis in esophageal cancer. Our recent clinical results from a phase I/II study of adenoviral-mediated p53 gene therapy for patients with un-resectable esophageal cancer are reviewed. Lastly we review the available experimental therapeutic models from the literature and our experimental work over the past few years are reviewed.

• Authors: Hideaki Shimada, Kazuyuki Matsushita, Masatoshi Tagawa
• Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia (Ann Thorac Cardiovasc Surg) Vol. 14 Issue 1 Pg. 3-8 (Feb 2008) ISSN: 1341-1098 [Print] Japan
• PMID: 18292732 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Viral Vaccines

Topics

• Animals
• Clinical Trials as Topic
• Combined Modality Therapy
• Esophageal Neoplasms (genetics, therapy)
• Genes, p53
• Genetic Therapy (trends)
• Genetic Vectors
• Humans
• Neovascularization, Pathologic (genetics)
• Viral Vaccines (therapeutic use)