Patterns of pregnancy exposure to prescription FDA C, D and X drugs in a Canadian population.

Abstract

OBJECTIVE:

To examine prescription Food and Drug Administration (FDA) C, D and X drugs in general obstetric population.

STUDY DESIGN:

Historical cohort study.

RESULT:

A total of 18 575 women who gave a birth in Saskatchewan between January 1997 and December 2000 were included. Among them, 3604 (19.4%) received FDA C, D or X drugs at least once during pregnancy. The pregnancy exposure rates were 15.8, 5.2 and 3.9%, respectively, for category C, D and X drugs, and were 11.2, 7.3 and 8.2%, respectively, in the first, second and third trimesters. Salbutamol (albuterol), trimethoprim/sulfamethoxazole (co-trimoxazole), ibuprofen, naproxen and oral contraceptives were the most common C, D, X drugs used during pregnancy.

CONCLUSION:

About one in every five women uses FDA C, D and X drugs at least once during pregnancy, and the most common prescription drugs in pregnancy are antiasthmatic, antibiotics, nonsteroid anti-inflammation drugs, antianxiety or antidepressants and oral contraceptives.

• Authors: S W Wen, T Yang, D Krewski, Q Yang, C Nimrod, P Garner, W Fraser, O Olatunbosun, M C Walker
• Journal: Journal of perinatology : official journal of the California Perinatal Association (J Perinatol) Vol. 28 Issue 5 Pg. 324-9 (May 2008) ISSN: 0743-8346 [Print] United States
• PMID: 18288118 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contraceptives, Oral
• Naproxen
• Trimethoprim, Sulfamethoxazole Drug Combination
• Albuterol
• Ibuprofen

Topics

• Adult
• Albuterol (administration & dosage, adverse effects)
• Contraceptives, Oral (administration & dosage)
• Cross-Sectional Studies
• Drug Prescriptions
• Drug-Related Side Effects and Adverse Reactions
• Female
• Gestational Age
• Humans
• Ibuprofen (administration & dosage, adverse effects)
• Infant, Newborn
• Naproxen (administration & dosage, adverse effects)
• Population Surveillance
• Pregnancy
• Prenatal Exposure Delayed Effects (chemically induced, epidemiology)
• Saskatchewan
• Trimethoprim, Sulfamethoxazole Drug Combination (administration & dosage, adverse effects)
• United States
• United States Food and Drug Administration