Screening for corticosteroid contact sensitivity. Comparison of tixocortol pivalate, hydrocortisone-17-butyrate and hydrocortisone.

Abstract

3 corticosteroids have so far been tried as markers for corticosteroid contact sensitivity: hydrocortisone, tixocortol pivalate and hydrocortisone-17-butyrate. The present study compared these steroids for screening in addition to a standard patch test series. Of 727 patients, 28 (3.9%) reacted to tixocortol pivalate and 10 (1.4%) to hydrocortisone-17-butyrate; hydrocortisone gave an allergic reaction in 2 of 521 (0.4%) patients. Serial dilutions suggested that tixocortol pivalate, not marketed in Finland, caused allergic reactions which could possibly be cross-reactions to hydrocortisone. In contrast to previously published data, frequent cross-reactions occurred with hydrocortisone-17-butyrate and tixocortol pivalate. All allergic reactions to other corticosteroids found by testing with tixocortol pivalate concurred with reactions to hydrocortisone-17-butyrate. The study suggests that the most effective choice for routine testing for corticosteroid contact sensitivity would be both tixocortol pivalate and hydrocortisone-17-butyrate.

• Authors: A I Lauerma
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 24 Issue 2 Pg. 123-30 (Feb 1991) ISSN: 0105-1873 [Print] England
• PMID: 1828209 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• hydrocortisone-17-butyrate
• tixocortol pivalate
• Hydrocortisone

Topics

• Administration, Topical
• Anti-Inflammatory Agents (adverse effects)
• Dermatitis, Contact (diagnosis, etiology)
• Drug Eruptions (diagnosis, etiology)
• Finland
• Humans
• Hydrocortisone (adverse effects, analogs & derivatives)
• Patch Tests
• Retrospective Studies