Elevated serum thiobarbituric acid reactive substances in clinically symptomatic schizophrenic males.

Abstract	Impaired antioxidant defenses are suggested to participate in the pathophysiology of schizophrenia. Altered superoxide dismutase (SOD) and increased lipid peroxidation, measured by the thiobarbituric acid reactive substances (TBARS), are increased in schizophrenia. The aim of this study was to determine the effects of clinical course and subtype on oxidative stress parameters. In this study, 68 male patients, classified according to DSM-IV schizophrenia subtypes and clinical course (partial remission, marked symptoms, and deteriorated), were studied, and TBARS and SOD measured. Mean serum SOD and mean serum TBARS concentrations were similarly not significantly different among different subtypes (paranoid, disorganized and undifferentiated). However, marked symptoms status was associated with higher TBARS levels compared to the deteriorated group. This suggests a possible relationship between symptom acuity and oxidative stress in males.
Authors	Clarissa Severino Gama, Mirian Salvador, Ana Cristina Andreazza, Maria Ines Lobato, Michael Berk, Flavio Kapczinski, Paulo Silva Belmonte-de-Abreu
Journal	Neuroscience letters (Neurosci Lett) Vol. 433 Issue 3 Pg. 270-3 (Mar 15 2008) ISSN: 0304-3940 [Print] Ireland
PMID	18255229 (Publication Type: Journal Article)
Chemical References	Antipsychotic Agents Biomarkers SOD1 protein, human Thiobarbituric Acid Reactive Substances Superoxide Dismutase Superoxide Dismutase-1
Topics	Adult Antipsychotic Agents (therapeutic use) Biomarkers (analysis, blood) Brain (drug effects, metabolism, physiopathology) Brain Chemistry (drug effects, physiology) Disease Progression Humans Male Middle Aged Oxidative Stress (drug effects, physiology) Predictive Value of Tests Schizophrenia (blood, diagnosis, physiopathology) Severity of Illness Index Sex Factors Superoxide Dismutase (analysis, blood) Superoxide Dismutase-1 Thiobarbituric Acid Reactive Substances (analysis, metabolism) Up-Regulation (drug effects, physiology)

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