Receptor-activity modifying protein 1 expression is increased in the striatum following repeated L-DOPA administration in a 6-hydroxydopamine lesioned rat model of Parkinson's disease.

Abstract	Abnormalities in signaling by G-protein coupled receptors (GPCRs) within the striatum are involved in the pathophysiology of Parkinson's disease (PD) and L-DOPA induced dyskinesia (LID). Receptor activity modifying proteins (RAMPs) are single transmembrane accessory proteins crucial for both trafficking and defining the phenotype of GPCRs. In the CNS, RAMP1 mRNA is predominantly expressed in striatum, cortex, and olfactory tubercles. In the present study, expression of RAMP1 mRNA is increased in the striatum (68-77%), following repeated L-DOPA administration, in the 6-hydroxydopamine-lesioned rat. These data are the first to describe regulation of RAMP1 expression in the CNS and suggest that changes in RAMP1 activity are involved in the pathophysiology of LID.
Authors	Joohyung Lee, Jordi Gomez-Ramirez, Tom H Johnston, Naomi Visanji, Jonathan M Brotchie
Journal	Synapse (New York, N.Y.) (Synapse) Vol. 62 Issue 4 Pg. 310-3 (Apr 2008) ISSN: 0887-4476 [Print] United States
PMID	18241048 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Adrenergic Agents Dopamine Agents Intracellular Signaling Peptides and Proteins Membrane Proteins RNA, Messenger Ramp1 protein, rat Receptor Activity-Modifying Protein 1 Receptor Activity-Modifying Proteins Levodopa Oxidopamine
Topics	Adrenergic Agents (toxicity) Animals Corpus Striatum (drug effects, metabolism) Disease Models, Animal Dopamine Agents (pharmacology) Dyskinesia, Drug-Induced (physiopathology) Gene Expression In Situ Hybridization Intracellular Signaling Peptides and Proteins Levodopa (pharmacology) Membrane Proteins (biosynthesis) Motor Activity (drug effects) Oxidopamine (toxicity) Parkinsonian Disorders (drug therapy, metabolism, physiopathology) RNA, Messenger (analysis) Rats Rats, Sprague-Dawley Receptor Activity-Modifying Protein 1 Receptor Activity-Modifying Proteins

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