Abstract | BACKGROUND: METHODS: 0.4% and 0.8% rapamycin ointments were applied to nude mice bearing subcutaneous, TSC-related tumors. Topical treatments were compared with injected rapamycin and topical vehicle. Rapamycin levels in blood and tumors were measured to assess systemic drug levels in all cohorts. RESULTS: Treatment with topical rapamycin improved survival and reduced tumor growth. Topical rapamycin treatment resulted in systemic drug levels within the known therapeutic range and was not as effective as injected rapamycin. CONCLUSION:
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Authors | Aubrey Rauktys, Nancy Lee, Laifong Lee, Sandra L Dabora |
Journal | BMC dermatology
(BMC Dermatol)
Vol. 8
Pg. 1
(Jan 28 2008)
ISSN: 1471-5945 [Electronic] England |
PMID | 18226258
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibiotics, Antineoplastic
- Enzyme Inhibitors
- Protein Kinases
- mTOR protein, mouse
- TOR Serine-Threonine Kinases
- Sirolimus
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Topics |
- Administration, Cutaneous
- Animals
- Antibiotics, Antineoplastic
(administration & dosage, pharmacokinetics)
- Cell Line, Tumor
- Disease Models, Animal
- Enzyme Inhibitors
(administration & dosage, pharmacokinetics)
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Protein Kinases
(drug effects)
- Sirolimus
(administration & dosage, pharmacokinetics)
- Skin Absorption
- Soft Tissue Neoplasms
(drug therapy, metabolism, pathology)
- Survival Analysis
- TOR Serine-Threonine Kinases
- Tuberous Sclerosis
(drug therapy, metabolism, pathology)
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