Abstract |
In the present study, we investigated effects of the dried, hot-water extract of Cordyceps militaris (CME) and its major metabolite ( cordycepin) against ischemic damage. The repeated treatment with CME protected hippocampal CA1 pyramidal neurons from ischemic damage in gerbils. The treatment with CME or cordycepin in gerbils reduced 4-hydroxy-2-nonenal (a marker of lipid peroxidation) immunoreactivity and levels in the ischemic CA1 region. Glial fibrillary acidic protein immunoreactive astrocytes and ionized calcium-binding adapter molecule 1 immunoreactive microglia in the vehicle-treated ischemic group were activated in the CA1 region 4 days after ischemia/reperfusion, whereas in the CME- or cordycepin-treated ischemic group, their activation was significantly decreased. These results suggest that the repeated treatment with CME protects against neuronal damage from ischemia/reperfusion by reducing oxidative damage.
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Authors | In Koo Hwang, Soon Sung Lim, Ki-Yeon Yoo, Yeon Sil Lee, Ho Gyoung Kim, Il-Jun Kang, Hyung Joo Kwon, Jinseu Park, Soo Young Choi, Moo-Ho Won |
Journal | Planta medica
(Planta Med)
Vol. 74
Issue 2
Pg. 114-9
(Feb 2008)
ISSN: 0032-0943 [Print] Germany |
PMID | 18214814
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aldehydes
- Antifungal Agents
- Biological Products
- Deoxyadenosines
- cordycepin
- Adenine
- 4-hydroxy-2-nonenal
- Adenosine
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Topics |
- Adenine
(pharmacology)
- Adenosine
(pharmacology)
- Aldehydes
(metabolism)
- Animals
- Antifungal Agents
(isolation & purification, pharmacology)
- Biological Products
(isolation & purification, pharmacology)
- Brain Injuries
(prevention & control)
- Cordyceps
(chemistry)
- Deoxyadenosines
(isolation & purification, pharmacology)
- Gerbillinae
- Hippocampus
(drug effects, injuries, physiology)
- Lipid Peroxidation
(drug effects)
- Male
- Neurons
(physiology)
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