Abstract | BACKGROUND: METHODS: Seven consecutive patients with confirmed AIMAH underwent unilateral adrenalectomy of the largest gland. ACTH and cortisol levels, arterial blood pressure (BP), glycometabolic parameters, and patient's subjective perception of health-related quality of life (by the SF-36 questionnaire) were measured preoperatively and postoperatively. RESULTS: No surgery-related morbidity occurred. One patient with a large contralateral adrenal enlargement required a completion adrenalectomy after 7 months because of persistent hypercortisolism. At a median follow-up of 53 (range, 27-68) months, the remaining six patients were cured, because serum and urinary free cortisol levels significantly decreased and ACTH increased, thus regaining the normal range. Both systolic and diastolic BP levels significantly reduced: 50% of patients definitively became normotensive, and the remaining patients reduced the need for antihypertensive treatment; 40% of patients suffering from preoperative diabetes were cured, whereas 40% reduced the need for hypoglycemizing drug. SF-36 evaluation of the health-related quality of life confirmed a significant amelioration. CONCLUSIONS:
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Authors | Maurizio Iacobone, Nora Albiger, Carla Scaroni, Franco Mantero, Ambrogio Fassina, Giovanni Viel, Mauro Frego, Gennaro Favia |
Journal | World journal of surgery
(World J Surg)
Vol. 32
Issue 5
Pg. 882-9
(May 2008)
ISSN: 0364-2313 [Print] United States |
PMID | 18214589
(Publication Type: Journal Article)
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Chemical References |
- Adrenocorticotropic Hormone
- Hydrocortisone
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Topics |
- Adrenal Glands
(pathology)
- Adrenalectomy
- Adrenocorticotropic Hormone
(blood)
- Adult
- Aged
- Female
- Follow-Up Studies
- Humans
- Hydrocortisone
(blood)
- Hyperplasia
(blood, diagnosis, surgery)
- Male
- Middle Aged
- Prospective Studies
- Quality of Life
- Time Factors
- Treatment Outcome
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