Combination echinocandin-polyene treatment of murine mucormycosis.

Abstract

We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect.

• Authors: Ashraf S Ibrahim, Teclegiorgis Gebremariam, Yue Fu, John E Edwards Jr, Brad Spellberg
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 52 Issue 4 Pg. 1556-8 (Apr 2008) ISSN: 0066-4804 [Print] United States
• PMID: 18212099 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Echinocandins
• Lipopeptides
• Lipoproteins
• Liposomes
• Polyenes
• Amphotericin B
• Anidulafungin
• Micafungin

Topics

• Amphotericin B (administration & dosage, therapeutic use)
• Anidulafungin
• Animals
• Antifungal Agents (administration & dosage, therapeutic use)
• Disease Models, Animal
• Drug Therapy, Combination
• Echinocandins (administration & dosage, therapeutic use)
• Humans
• Lipopeptides
• Lipoproteins (administration & dosage, therapeutic use)
• Liposomes (administration & dosage, therapeutic use)
• Male
• Micafungin
• Mice
• Mice, Inbred BALB C
• Mucormycosis (drug therapy, microbiology)
• Polyenes (administration & dosage, therapeutic use)
• Rhizopus (classification, drug effects)
• Treatment Outcome