Abstract | OBJECTIVE: DESIGN: Retrospective case series analysis. SETTING: Department of Dermatology, Nagasaki University Graduate School of Biomedical Science. PATIENTS: MAIN OUTCOME MEASURES: Prevalence, immunoglobulin subclass distribution, and clinical correlation of Abs, especially of IgE Abs, to BP180 and BP230. RESULTS:
IgG anti-BP180 and anti-BP230 Abs were detected in 35 (95%) and 26 (70%) of the 37 BP serum samples, respectively. IgG1 and IgG4 isotypes were positive in 32 (87%) and 25 (68%), respectively, of the BP serum samples for anti-BP180 Abs, while they were detected in 16 (44%) and 26 (70%), respectively, for anti-BP230 Abs. IgE anti-BP180 and anti-BP230 Abs were equally detected in 8 (22%) of the BP serum samples. Similar to IgG anti-BP180 Abs, the presence or levels of IgE anti-BP180 Abs was associated with broader skin lesions. Furthermore, patients with BP positive for IgE anti-BP180 Abs required longer duration for remission, higher dosage of prednisolone, and more intensive therapies for remission. By contrast, this was not true for those with of IgE anti-BP230 Abs. Remarkably, when analyzed in patients with BP who had a high titer of IgG anti-BP180 Abs, the presence or levels of IgE anti-BP180 Abs, but not IgG anti-BP180 Abs, were associated with a more severe form. CONCLUSIONS: The present study suggests that IgE anti-BP180 Abs are related to the disease severity and activity of BP. Moreover, it may be possible to identify treatment-refractory patients with BP more specifically by assessing the presence or levels of IgE anti-BP180 Abs in those with a high IgG anti-BP180 Ab titer.
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Authors | Yohei Iwata, Kazuhiro Komura, Masanari Kodera, Toshikazu Usuda, Yoko Yokoyama, Toshihide Hara, Eiji Muroi, Fumihide Ogawa, Motoi Takenaka, Shinichi Sato |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 144
Issue 1
Pg. 41-8
(Jan 2008)
ISSN: 1538-3652 [Electronic] United States |
PMID | 18209167
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Autoantigens
- Biomarkers
- Non-Fibrillar Collagens
- Immunoglobulin E
- Prednisone
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Topics |
- Aged
- Autoantibodies
(blood)
- Autoantigens
(blood)
- Biomarkers
(blood)
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- Female
- Follow-Up Studies
- Humans
- Immunoglobulin E
(blood)
- Japan
- Male
- Middle Aged
- Non-Fibrillar Collagens
(blood)
- Pemphigoid, Bullous
(blood, diagnosis, drug therapy, immunology)
- Prednisone
(therapeutic use)
- Probability
- Reference Values
- Retrospective Studies
- Risk Assessment
- Sensitivity and Specificity
- Severity of Illness Index
- Statistics, Nonparametric
- Collagen Type XVII
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