Photodynamic activity of platinum(IV) chloride surface-modified TiO2 irradiated with visible light.

Abstract

The visible light-induced phototoxicity of titanium dioxide modified with platinum(IV) chloride complexes, [TiO2/PtCl4], was tested. In vitro experiments with the mouse melanoma cells (S-91) have demonstrated phototoxicity of the [TiO2/PtCl4] material. Detection of efficiently generated various reactive oxygen species (.OH, O2. -, H2O2, 1O2) and also reactive chlorine species has proven the photodynamic activity of the tested material, induced by visible light (lambda>455 nm). The cellular death (recognized as a necrosis) is a result of the cell membrane peroxidation.

• Authors: Agnieszka Jańczyk, Agnieszka Wolnicka-Głubisz, Krystyna Urbanska, Horst Kisch, Grazyna Stochel, Wojciech Macyk
• Journal: Free radical biology & medicine (Free Radic Biol Med) Vol. 44 Issue 6 Pg. 1120-30 (Mar 15 2008) ISSN: 0891-5849 [Print] United States
• PMID: 18194674 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Photosensitizing Agents
• Platinum Compounds
• Reactive Oxygen Species
• platinum chloride
• titanium dioxide
• Titanium

Topics

• Animals
• Cell Line, Tumor
• Light
• Mice
• Necrosis (metabolism)
• Photochemotherapy (methods)
• Photosensitizing Agents (chemistry, pharmacology)
• Platinum Compounds (chemistry, pharmacology)
• Reactive Oxygen Species (metabolism)
• Spin Trapping
• Titanium (chemistry, pharmacology)