Abstract | INTRODUCTION: METHODS: RESULTS: CONCLUSION: Altogether, our data suggest that extracellular calcium, probably through its binding to ibandronate, markedly increased its cellular accumulation and its inhibitory activity on breast tumour cells. Thus, calcium released during the process of tumour-induced osteolysis might enhance the antitumour effects of bisphosphonates and contribute to their therapeutic efficacy.
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Authors | Fabrice Journé, Naïma Kheddoumi, Carole Chaboteaux, Hugues Duvillier, Guy Laurent, Jean-Jacques Body |
Journal | Breast cancer research : BCR
(Breast Cancer Res)
Vol. 10
Issue 1
Pg. R4
( 2008)
ISSN: 1465-542X [Electronic] England |
PMID | 18190680
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Diphosphonates
- Imidazoles
- Zoledronic Acid
- Calcium
- Ibandronic Acid
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Topics |
- Antineoplastic Agents
(pharmacology)
- Apoptosis
(drug effects)
- Bone and Bones
(drug effects, metabolism)
- Breast Neoplasms
(drug therapy)
- Calcium
(pharmacology)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Diphosphonates
(pharmacology)
- Drug Synergism
- Female
- Humans
- Ibandronic Acid
- Imidazoles
(pharmacology)
- Zoledronic Acid
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