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Mechanisms of resistance to daptomycin in Enterococcus faecium.

Abstract
In this study, we investigated the clonal emergence of daptomycin-resistant Enterococcus faecium strains isolated from a patient with leukocyte adhesion deficiency syndrome. The resistance mechanism in these strains is independent of either equivalent point mutations previously described for Staphylococcus aureus or daptomycin inactivation mechanisms identified in soil bacteria.
AuthorsClemente I Montero, Frida Stock, Patrick R Murray
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 52 Issue 3 Pg. 1167-70 (Mar 2008) ISSN: 0066-4804 [Print] United States
PMID18180351 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • DNA, Bacterial
  • Vancomycin
  • Daptomycin
Topics
  • Anti-Bacterial Agents (pharmacology)
  • Bacterial Proteins (genetics)
  • DNA, Bacterial (analysis, isolation & purification)
  • Daptomycin (pharmacology)
  • Drug Resistance, Bacterial (genetics)
  • Electrophoresis, Gel, Pulsed-Field
  • Enterococcus faecium (drug effects, genetics, isolation & purification)
  • Gram-Positive Bacterial Infections (microbiology)
  • Humans
  • Leukocyte-Adhesion Deficiency Syndrome (microbiology)
  • Microbial Sensitivity Tests
  • Point Mutation
  • Polymerase Chain Reaction
  • Vancomycin (pharmacology)

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