PON1 activity and total oxidant status in patients with active pulmonary tuberculosis.

Abstract

OBJECTIVES:

The aim of this study was to the investigate effect of tuberculosis infection on paraoxonase-1 (PON1) activity and oxidative status in patients with pulmonary tuberculosis (PTB).

DESIGN AND METHODS:

Twenty-five active PTB subjects and 33 healthy controls were included in the study. Serum PON1 activity, total oxidant status (TOS), lipid hydroperoxide (LOOH) and total free sulfydryl (-SH) groups were determined.

RESULTS:

Serum basal/salt-stimulated paraoxonase activities, arylesterase activity and total -SH group levels were significantly lower in patients with PTB than controls (p<0.05, p<0.05, p<0.001 and p<0.01 respectively), while TOS and LOOH levels were significantly higher (p<0.01 and p<0.05, respectively). In PTB patients, TOS, LOOH and total -SH group levels were significantly correlated with paraoxonase (r=-0.371, p<0.05; r=-0.286, p<0.05; r=0.625 p<0.01; respectively) and arylesterase (r=-0.437, p<0.01; r=-0.352, p<0.05; r=0.653, p<0.01; respectively).

CONCLUSIONS:

Patients with active PTB are exposed to potent oxidative stress and they have decreased PON1 activity. These predisposal factors may, in part, play a role in the pathogenesis of atherosclerosis in PTB.

• Authors: Sahbettin Selek, Niyet Cosar, Abdurrahim Kocyigit, Ozcan Erel, Nurten Aksoy, Mehmet Gencer, Faruk Gunak, Mehmet Aslan
• Journal: Clinical biochemistry (Clin Biochem) Vol. 41 Issue 3 Pg. 140-4 (Feb 2008) ISSN: 0009-9120 [Print] United States
• PMID: 18154731 (Publication Type: Journal Article)

Chemical References

• Lipid Peroxides
• Oxidants
• Sulfhydryl Compounds
• Aryldialkylphosphatase

Topics

• Adult
• Aryldialkylphosphatase (blood)
• Atherosclerosis (blood, etiology)
• Female
• Humans
• Lipid Peroxides (blood)
• Male
• Middle Aged
• Oxidants (blood)
• Oxidation-Reduction
• Oxidative Stress
• Reference Values
• Sulfhydryl Compounds (blood)
• Tuberculosis, Pulmonary (blood, complications)