Association between inflammatory markers and the interleukin-6 -174 G/C polymorphism is abolished in peripheral arterial occlusive disease.

Abstract

AIM:

The interleukin-6 (IL-6) -174 G/C polymorphism has been reported to determine IL-6 levels and contribute to the development of cardiovascular disorders. The aim of our study was to evaluate the effect of the IL-6 -174 G/C polymorphism on hemostatic or inflammatory markers in patients with peripheral arterial occlusive disease (PAOD), a common manifestation of obliterative atherosclerosis.

METHODS:

Plasma IL-6, fibrinogen, C-reactive protein (CRP), tissue plasminogen activator, plasminogen activator inhibitor-1 (PAI-1), fibrinopeptide A and intercellular adhesion molecule-1 levels were determined in PAOD patients (n=50) and healthy controls (n=30) genotyped for the IL-6 -174 G/C polymorphism.

RESULTS:

In the control group, IL-6, CRP and fibrinogen levels were significantly associated with the IL-6 -174 G/C polymorphism with a gene-dosage effect being the highest in the CC subjects and the lowest in those with the GG genotype (P<0.0001, P=0.0002 and P=0.0001, respectively). Interestingly, the CC homozygotes had lower PAI-1 levels than carriers of the G allele (P=0.04). In PAOD patients, the IL-6 -174 G/C polymorphism had no effect on all the variables measured.

CONCLUSION:

In contrast to apparently healthy subjects, the IL-6 -174 G/C polymorphism showed no association with plasma IL-6, CRP, fibrinogen and PAI-1 levels in PAOD patients.

• Authors: D P Potaczek, A Undas, T Nowakowski, A Szczeklik
• Journal: International angiology : a journal of the International Union of Angiology (Int Angiol) Vol. 26 Issue 4 Pg. 318-23 (Dec 2007) ISSN: 0392-9590 [Print] Italy
• PMID: 18091699 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acute-Phase Proteins
• Blood Coagulation Factors
• Interleukin-6

Topics

• Acute-Phase Proteins (metabolism)
• Adult
• Arterial Occlusive Diseases (blood, genetics)
• Blood Coagulation Factors (metabolism)
• Case-Control Studies
• Female
• Genotype
• Humans
• Interleukin-6 (genetics)
• Male
• Middle Aged
• Peripheral Vascular Diseases (blood, genetics)
• Polymorphism, Genetic (genetics)