Antimicrobial activity of tigecycline against community-acquired methicillin-resistant Staphylococcus aureus isolates recovered from North American medical centers.

Abstract

A total of 1989 community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) were susceptibility tested by broth microdilution. Pulsed-field gel electrophoresis, SCCmec type, and polymerase chain reaction for Panton-Valentine leukocidin (PVL) genes were also performed. The overall tigecycline susceptibility rate was 98.2%. Glycopeptides, quinupristin/dalfopristin, linezolid, and chloramphenicol were also active against this collection (< or =0.7% resistant). The vast majority (70.8%) of the CA-MRSA was SCCmec type IV, from which 88.4% belonged to the USA300-0114 clone and 94.7% were PVL positive. Tigecycline showed in vitro activity comparable with other highly active parenteral agents and represents an option for treating complicated infections caused by CA-MRSA.

• Authors: Rodrigo E Mendes, Helio S Sader, Lalitagauri Deshpande, Ronald N Jones
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 60 Issue 4 Pg. 433-6 (Apr 2008) ISSN: 0732-8893 [Print] United States
• PMID: 18068326 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Bacterial Toxins
• DNA, Bacterial
• Exotoxins
• Leukocidins
• Panton-Valentine leukocidin
• Tigecycline
• Minocycline

Topics

• Academic Medical Centers
• Anti-Bacterial Agents (pharmacology)
• Bacterial Toxins (genetics)
• Community-Acquired Infections (microbiology)
• DNA Fingerprinting
• DNA, Bacterial (genetics)
• Electrophoresis, Gel, Pulsed-Field
• Exotoxins (genetics)
• Genotype
• Humans
• Leukocidins (genetics)
• Methicillin Resistance (genetics)
• Microbial Sensitivity Tests
• Minocycline (analogs & derivatives, pharmacology)
• North America
• Staphylococcal Infections (microbiology)
• Staphylococcus aureus (classification, drug effects, genetics, isolation & purification)
• Tigecycline