Carboranyl thymidine analogues for neutron capture therapy.

Abstract

Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment of cancer. A major focus of NCT-related research is the development of novel tumor-selective agents that serve as the chemical component in NCT. Thymidine analogues substituted with a boron-containing carborane cluster at the N3 position, designated 3CTAs (3-carboranyl thymidine analogues), constitute one class of these new improved NCT agents. Their chemical, structural and biological properties are discussed in this Feature Article.

• Authors: Werner Tjarks, Rohit Tiwari, Youngjoo Byun, Sureshbabu Narayanasamy, Rolf F Barth
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Issue 47 Pg. 4978-91 (Dec 21 2007) ISSN: 1359-7345 [Print] England
• PMID: 18049729 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Boron Compounds
• Phosphotransferases
• Boron
• Thymidine

Topics

• Animals
• Boron (chemistry)
• Boron Compounds (chemistry, therapeutic use)
• Disease
• Humans
• Neutron Capture Therapy
• Phosphotransferases (metabolism)
• Thymidine (analogs & derivatives, chemistry, therapeutic use)