The role of ketoconazole in seborrheic dermatitis.

Abstract

Although the prominent broad-spectrum activity of ketoconazole was reported in the early 1980s, its effect against Malassezia species was most pronounced; thus, it was developed for the treatment of various skin infections in which a link with these fungal species was proposed. Later, a number of ancillary properties were described for ketoconazole that comprised its anti-inflammatory, antiseborrheic, and antiproliferative profile. The incorporation of ketoconazole in an adapted vehicle could further promote its efficacy. Recently, a new formulation-an anhydrous gel containing ketoconazole 2%-was launched in which all of the ancillary properties were optimized.

• Authors: Marcel Borgers, Hugo Degreef
• Journal: Cutis (Cutis) Vol. 80 Issue 4 Pg. 359-63 (Oct 2007) ISSN: 0011-4162 [Print] United States
• PMID: 18038701 (Publication Type: Journal Article, Review)

Chemical References

• Antifungal Agents
• Gels
• Ketoconazole

Topics

• Administration, Topical
• Antifungal Agents (administration & dosage, pharmacology)
• Dermatitis, Seborrheic (drug therapy, microbiology)
• Dermatomycoses (complications, drug therapy)
• Gels
• Humans
• Ketoconazole (administration & dosage, pharmacology)
• Malassezia