Lipid peroxidation in stroke patients.

Abstract

BACKGROUND:

Paraoxonase is high-density lipoprotein (HDL)-associated esterase/lactonase implicated to play a role in the antioxidant and anti-inflammatory properties exerted by HDL. Increasing evidence support a role of free radicals and oxidative stress in neuronal damage induced by ischemia-reperfusion. The aim of this study was to further investigate the relationship between lipoprotein oxidative damage and stroke.

METHODS:

We compared the paraoxonase activity and levels of lipid hydroperoxides in plasma isolated from healthy subjects (n=50) and from stroke patients (n=49). Moreover, the correlations between biochemical markers and the National Institute of Health Stroke Scale (NIHSS), which is widely used to study neurological severity, were evaluated.

RESULTS:

Our results demonstrated, for the first time, that the activity of paraoxonase in plasma of stroke subjects was significantly lower than controls (p<0.001) and the levels of lipid hydroperoxides were significantly higher in plasma from patients (p<0.001). Moreover, using linear regression analysis, significant correlations between the activity of paraoxonase, lipid peroxidation and the severity of neurological deficit at admission were observed.

CONCLUSIONS:

These results provide further evidence that oxidative stress and impairment of the antioxidant system may play a role in stroke. Antioxidant activity of plasma may be an important factor providing protection from neurological damage caused by stroke-associated oxidative stress.

• Authors: Gianna Ferretti, Tiziana Bacchetti, Simona Masciangelo, Laura Nanetti, Laura Mazzanti, Mauro Silvestrini, Marco Bartolini, Leandro Provinciali
• Journal: Clinical chemistry and laboratory medicine (Clin Chem Lab Med) Vol. 46 Issue 1 Pg. 113-7 ( 2008) ISSN: 1434-6621 [Print] Germany
• PMID: 18034641 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Lipid Peroxides
• Lipoproteins, HDL
• Triglycerides
• Cholesterol
• Aryldialkylphosphatase
• PON1 protein, human

Topics

• Antioxidants (metabolism)
• Aryldialkylphosphatase (blood)
• Cholesterol (blood)
• Humans
• Lipid Peroxidation (physiology)
• Lipid Peroxides (blood)
• Lipoproteins, HDL (blood)
• Nervous System Diseases (metabolism, pathology)
• Oxidative Stress (physiology)
• Reference Values
• Stroke (metabolism, pathology)
• Time Factors
• Triglycerides (blood)