Keratin and filaggrin expression in keratoacanthoma.

Abstract

To clarify the histogenesis of keratoacanthoma, we studied keratin (K) expression in keratoacanthoma (KA) using 10 different anti-keratin antibodies against K1, K7, K8, K10, K14, K15, K16, K17, K18 and K19 and anti-filaggrin (filament aggregating protein) antibody. In the centre of KA, K1 and K10 expressions were declined, and K14 and K16 were detected in the tumour cells, suggesting differentiation towards the outer root sheath beneath the orifice of the sebaceous duct. These results suggest that KA differentiates towards the outer root sheath beneath the opening of the sebaceous duct.

• Authors: Yoshiyuki Ito, Ichiro Kurokawa, Keisuke Nishimura, Arata Hakamada, Ken-ichi Isoda, Kei-ichi Yamanaka, Airo Tsubura, Hitoshi Mizutani
• Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 22 Issue 3 Pg. 353-5 (Mar 2008) ISSN: 1468-3083 [Electronic] England
• PMID: 18005116 (Publication Type: Journal Article)

Chemical References

• FLG protein, human
• Filaggrin Proteins
• Intermediate Filament Proteins
• Keratin-1
• Keratin-14
• Keratin-16
• Keratin-10
• Keratins

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Female
• Filaggrin Proteins
• Gene Expression Regulation, Neoplastic
• Humans
• Intermediate Filament Proteins (metabolism)
• Keratin-1 (metabolism)
• Keratin-10 (metabolism)
• Keratin-14 (metabolism)
• Keratin-16 (metabolism)
• Keratins (metabolism)
• Keratoacanthoma (metabolism, pathology)
• Male
• Middle Aged
• Sebaceous Gland Neoplasms (metabolism, pathology)
• Sebaceous Glands (metabolism, pathology)
• Skin (pathology)