Abstract |
A case of intracerebral nodular leukemic mass that developed in a girl eight years after a diagnosis of acute lymphoblastic leukemia (ALL) and 18 months after second discontinuation of therapy for a central nervous system (CNS) relapse is reported. The morphologic picture and the long time that elapsed from the diagnosis raised the suspicion of a cerebral neoplasm; the immediate and dramatic effect of steroid treatment, on the contrary, indicated the presence of a leukemic infiltration and in the meantime, a bone marrow relapse occurred. The patient soon after received high-dose Cytosine Arabinoside (HD ARA C) + Vincristine (VCR) + Levo- Asparaginase (L-ASE) + Prednisone (PDN) without any intrathecal antiblastic drug. We observed a neurological recovery and a complete disappearance of the mass. After consolidation of the remission the patient began an ablative regimen for bone marrow transplantation. The efficacy of HD ARA C in the treatment of the intracerebral nodular leukemic mass is emphasized.
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Authors | A Corbetta, M Jankovic, V Conter, T Fuga, M Crivellaro, G Masera |
Journal | Haematologica
(Haematologica)
1991 Jul-Aug
Vol. 76
Issue 4
Pg. 324-6
ISSN: 0390-6078 [Print] Italy |
PMID | 1794739
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytarabine
- Vincristine
- Dexamethasone
- Asparaginase
- Prednisone
- Methotrexate
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Aphasia
(etiology)
- Asparaginase
(administration & dosage)
- Blood-Brain Barrier
- Bone Marrow Transplantation
- Brain Neoplasms
(complications, diagnosis, drug therapy, epidemiology, prevention & control)
- Child, Preschool
- Combined Modality Therapy
- Cranial Irradiation
- Cytarabine
(administration & dosage, pharmacokinetics)
- Dexamethasone
(administration & dosage)
- Female
- Humans
- Intracranial Pressure
- Methotrexate
(administration & dosage)
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(pathology, therapy)
- Prednisone
(administration & dosage)
- Remission Induction
- Vincristine
(administration & dosage)
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