Helicobacter pylori: immunoproteomics related to different pathologies.

Abstract

Helicobacter pylori is a Gram-negative bacterium that causes ulcer, atrophic gastritis, adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. Moreover, an ongoing controversial role of this bacterium infection has been suggested in the etiopathogenesis of some extradigestive diseases. The humoral response to H. pylori during a natural infection can be used for diagnostic purposes and as a basis for vaccine development. Host-pathogen interactions may be investigated by means of immunoproteomics, which provides global information about relevant specific and nonspecific antigens, and thus might be suitable to identify novel vaccine candidates or serological markers of H. pylori infection as well as of different related diseases. In this review, we describe how several research groups used H. pylori proteomics combined with western blotting analysis, using sera from patients affected with different H. pylori-related pathologies, to investigate potential associations between host immune response and clinical outcomes of H. pylori infection, resulting in the rapid identification of novel, highly immunoreactive antigens.

• Authors: Giulia Bernardini, Daniela Braconi, Paola Lusini, Annalisa Santucci
• Journal: Expert review of proteomics (Expert Rev Proteomics) Vol. 4 Issue 5 Pg. 679-89 (Oct 2007) ISSN: 1744-8387 [Electronic] England
• PMID: 17941822 (Publication Type: Journal Article, Review)

Chemical References

• Virulence Factors

Topics

• Gastritis (microbiology)
• Helicobacter Infections (diagnosis, immunology, pathology)
• Helicobacter pylori (immunology, pathogenicity)
• Humans
• Proteomics (methods)
• Stomach (microbiology, pathology)
• Virulence Factors